Marine Ecology

Microbial and chemical biodiversity

 

Marine microbes are an important resource for bioactive compounds with tremendous possibilities e.g. for application for health and biotechnology. In the ecological context, bioactive compounds are considered to have functions in cellular communication, signalling and in the defence against predators and pathogens. Therefore, they may play a significant role in shaping interactions and forming the structure of marine communities. The genetic/genomic potential for natural product biosynthesis, the characterization of substances produced by marine microorganisms, their role in microbial interactions as well as applied aspects of natural products are within the focus of present and future research of MI.

 

References

  1. Abdelmohsen UR , Balasubramanian S, Oelschlaeger TA, Grkovic T, Pham NB, Quinn RJ, Hentschel U. (2017) Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections. Lancet Infect Dis: pii: S1473-3099(16)30323-1. doi: 10.1016/S1473-3099(16)30323-1.
  2. Wiese, J., Aldemir, H., Schmaljohann, R., Gulder, T.A.M., Imhoff, J.F. 2017. Asperentin B, a new inhibitor of the protein tyrosine phosphatase 1B. Mar. Drugs 15, 191;doi:10.3390/md15060191.
  3. Andrea Gärtner, Jutta Wiese, Johannes F. Imhoff. 2016. Diversity of Micromonospora strains from the deep Mediterranean Sea and their potential to produce bioactive compounds. AIMS Microbiology 2: 205-221.
  4. Horn H, Cheng C, Edrada-Ebel R, Hentschel U, Abdelmohsen UR (2015) Draft genome sequences of three chemically rich actinomycetes isolated from Mediterranean sponges. Mar Genomics: Pt 3: 285-287. doi: 10.1016/j.margen.2015.10.003[HHU1] .
  5. Cheng C, MacIntyre L, Abdelmohsen UR, Horn H, Polymenakou PN, Edrada-Ebel R, Hentschel U (2015) Biodiversity, anti-trypanosomal activity screening, and metabolomic profiling of actinomycetes isolated from Mediterranean sponges. PLoS One: 10(9):e0138528. doi: 10.1371/journal.pone.0138528.
  6. Wu, B., Wiese, J., Labes, A., Kramer, A. Schmaljohann, R., and J.F. Imhoff. 2015. Lindgomycin , an unusual antibiotic polyketide from a marine fungus of the Lindgomycetaceae. Mar. Drugs 13: 4617-4632.

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