Dr. Pradeep Dewapriya

Research Division 3: Marine Ecology
RU Marine Natural Products Chemistry

Office:
Room: KW-23
Phone: +49 431 600-4440
Fax: +49 431 600-4441
E-Mail: pdewapriya(at)geomar.de

Address:
Am Kiel-Kanal 44
D-24106 Kiel

  • Research Interests

My research is focused on development and application of mass spectrometry-based analytical tools to explore secondary metabolome of microorganisms associated with marine organisms to discover biologically active small molecules (natural products). I aim to better understand the potential of microbial secondary metabolites in drug discovery while exploring their ecological roles.

  • Academic positions

Postdoctoral researcher in Analytical Marine Natural Products Chemistry at GEOMAR, Research Unit Marine Natural Products Chemistry/ GEOMAR-Biotech, Kiel, Germany, since March 2019

PhD in Microbial Natural Products Chemistry, Institute for Molecular Bioscience (IMB), The University of Queensland, Australia, 2014 – 2019

  • Publications

Jiao, W.H., Dewapriya, P., Mohamed, O., Khalil, Z.G., Salim, A.A., Lin, H.W., Capon, R.J. Divirensols: Sesquiterpene dimers from the Australian termite nest-derived fungus Trichoderma virens CMB-TN16. Journal of Natural Products, 2019, 82 (1), 87–95, doi:10.1021/acs.jnatprod.8b00746.

McAlpine, J.B., Chen, S.N.,…Dewapriya, P,…... et al. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 2018, 36(1), 35-107, doi: 10.1039/c7np00064b.

Dewapriya, P., Khalil Z, G., Prasad P., Salim A.A., Morales P.C., Marcellin E., Capon R.J. Talaropeptides A–D: Structure and biosynthesis of extensively N-methylated linear peptides from an Australian marine tunicate-derived Talaromyces sp. Frontiers in Chemistry, 2018, 6 (394), 1–15, doi: 10.3389/fchem.2018.00394.

Jiao,W.H., Khalil, Z., Dewapriya, P., Salim, A.A., Lin, H.W., Capon, R.J. Trichodermides A−E: New peptaibols isolated from the Australian termite nest-derived fungus Trichoderma virens CMB-TN16. Journal of Natural Products, 2018, 81 (4), 976–984, doi: 10.1021/acs.jnatprod.7b01072.

Forster, L.C., Pierens, G.K., White, A.M., Cheney, K.L, Dewapriya, P., Capon, R.J., Garson, M.J. Cytotoxic spiroepoxide lactone and its putative biosynthetic precursor from Goniobranchus Splendidus. ACS Omega, 2017, 2(6) 2672-2677, doi: 10.1021/acsomega.7b00641.

Dewapriya, P., Prasad P., Damodar, R., Salim, A.A., Capon R. J. Talarolide A, a cyclic heptapeptide hydroxamate from an Australian marine tunicate-associated fungus, Talaromyces sp. (CMB-TU011). Organic Letters, 2017, 19 (8), 2046–2049, doi: 10.1021/acs.orglett.7b00638.

Forster, L.C., Winters, A. E., Cheney, K.L., Dewapriya, P., Capon R. J., Garson, M. J. Spongian-16-one diterpenes and their anatomical distribution in the Australian nudibranch Goniobranchus collingwoodi. Journal of Natural Products, 2017, 80 (3), 670–675, doi: 10.1021/acs.jnatprod.6b00936.

Li, Y.X., Himaya, S.W.A., Dewapriya, P., Kim, H.J., Kim, S.K. Anti-proliferative effects of isosclerone isolated from marine fungus Aspergillus fumigatus in MCF-7 human breast cancer cells. Process Biochemistry, 2014, 49(12), 2292-2298, doi: 10.1016/j.procbio.2014.08.016.

Dewapriya, P., Li, Y.X., Himaya, S.W.A., Kim, S.K. Isolation and characterization of marine-derived Mucor sp. for the fermentative production of tyrosol. Process Biochemistry, 2014, 49 (9) 1402–1408, doi: 10.1016/j.procbio.2014.06.004.

Dewapriya, P., Kim, S.K. Marine microorganisms: An emerging avenue in modern nutraceuticals and functional foods. Food Research International, 2014, 56, 115–125, doi: 10.1016/j.foodres.2013.12.022.

Kim, M.J., Li, Y.X., Dewapriya, P., Ryu, B.M., Kim, S.K. Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia. BMB Reports, 2013, 46(8), 398, doi: 10.5483/BMBRep.2013.46.8.237.

Li, Y.X., Himaya, S.W.A., Dewapriya, P., Zang, C., Kim, S.K. Fumigaclavine C from marine-derived fungus Aspergillus fumigatus induces apoptosis in MCF-7 breast cancer cells. Marine Drugs, 2013, 11(12) 5063–5086, doi: 10.3390/md11125063.

Dewapriya, P., Li, Y.X., Himaya, S.W.A., Pangestuti, R., Kim, S.K. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity. NeuroToxicology, 2013, 35, 30–40, doi: 10.1016/j.neuro.2012.12.004.

Dewapriya, P., Himaya, S.W.A., Li, Y.X., Kim, S.K. Tyrosol exerts a protective effect against dopaminergic neuronal cell death in In vitro model of Parkinson’s disease. Food Chemistry, 2013, 144(2), 1147–1157, doi: 10.1016/j.foodchem.2013.04.004.

Himaya, S.W.A., Dewapriya P., Kim, S.K. EGFR tyrosine kinase inhibitory peptide attenuates Helicobacter pylori-mediated hyper proliferation in AGS enteric epithelial cells. Toxicology Applied Pharmacology, 2013, 269(3), 205–214, doi:  10.1016/j.taap.2013.03.020.

  • Poster Presentation

Dewapriya, P., Khalil, Z., Prasad, P., Salim, A.A., Morales, P. C., Marcellin, E., Capon, R.J. “Talaropeptides A–D: Structure and biosynthesis of extensively N-methylated linear peptides from an Australian marine tunicate-derived Talaromyces sp. CMB-TU011”, In 2018 American Society of Pharmacognosy Annual Meeting (ASP 2018), July 21–25, 2018, Lexington, KY.

Dewapriya, P., Himaya, S.W.A., Li, Y.X., Kim S.K. “Protective effect of tyrosol on MPP+-induced dopaminergic neuronal degradation in cellular model of Parkinson’s disease”, In 2013 International Conference on Life Science & Biological Engineering, March 15-17, 2013, Tokyo, Japan.