Prof. Dr. Deniz Tasdemir

Leiterin der Forschungseinheit Marine Naturstoffchemie

Direktorin des GEOMAR-Biotech: GEOMAR Zentrum für Marine Biotechnologie

Büro:
Raum: 15
Tel.: +49 431 600-4430
Fax: ++49 431 600-4441
E-Mail: dtasdemir(at)geomar.de

Teamassistenz
Christina Mausolf
Tel.: ++49-431 600-4437
Fax: ++49-431 - 600-4441
E-Mail: cmausolf(at)geomar.de

Anschrift:
FE Marine Naturstoffchemie
GEOMAR Zentrum für Marine Biotechnologie (GEOMAR-Biotech)
Am Kiel-Kanal 44 | 24106 Kiel | Germany

Education and Career Stages

- Full Professor of Marine Natural Products Chemistry at GEOMAR, since August 2014

- Full Professor of Marine Biodiscovery, National University of Ireland Galway, School of Chemistry, Ireland, 2011

- Senior lecturer at London School of Pharmacy (now UCL School of Pharmacy), UK, 2006

- Dr. Helmut Legerlotz Fellow, University of Zurich, Institute of Organic Chemistry, Switzerland, 2002

- Post-doctoral fellow, University of Utah, College of Pharmacy, USA, 1998-2001

- Assistant Professor, Hacettepe University, Ankara, Turkey, 1998

- PhD (Hons) at ETH Zurich, Department of Pharmacy, Switzerland, 1997

- MSc (Hons) in Pharmacognosy, Hacettepe University, Turkey

- BSc (Hons) in Pharmacy, Hacettepe University, Ankara, Turkey

Distinctions and Awards

- Waters Award for Excellence in Natural Products Innovation, 2016

- Egon Stahl Silver Medal of Society for Medicinal Plant Research (GA), 2005

- Pierre Fabre Prize of the Phytochemical Society of Europe (PSE), 2004

- ETH-Zurich Medal, Distinction for PhD Thesis, 1997

- Science Motivation Award and Ihsan Dogramacı Award for Excellent Success in Education: Graduation with the highest honors at Faculty of Pharmacy, Hacettepe University

 

Editorial Functions

- Member of the Editorial Board of Marine Drugs

- Member of the Advisory Editorial Board of Planta Medica

- Member of the Editorial Board of Phytochemistry Letters

- Member of the Editorial Board of Frontiers in Ethnopharmacology

- Guest Editor, Marine Drugs, Special issue: Selected papers from the 2nd International Conference of Marine Fungal Natural Products, On-going

- Guest Editor, Planta Medica, Special issue in marine natural products, vol. 82, issues 9/10, June 2016)

- Guest Editor, Journal of Natural Products, Special issue in honor of Professor Otto Sticher (with M. Hamburger and J. Orjala, vol. 77, issue 3, March 2014)

- Guest Editor, Marine Drugs, Special issue: Antiprotozoal marine natural products, Nov. 2013 (http://www.mdpi.com/journal/marinedrugs/special_issues/antiprotozoal_marine)

 

Functions in Learned Natural Product Societies

- Member of the Advisory Board of Society for Medicinal Plant and Natural Product Research (GA). Since 2009

- Member of the Permanent Committee of Young Researchers Workshop, Society for Medicinal Plant and Natural Product Research (GA). 2009 - 2015

- Membership secretary of the Phytochemical Society of Europe (PSE). 2008- 2013

 

Selected Publications

Parrot D., Blümel M., Utermann, C., Chianese G., Krause S., Kovalev, A., Gorb, S.N., Tasdemir, D. Mapping the surface microbiome and metabolome of brown seaweed Fucus vesiculosus by amplicon sequencing, integrated metabolomics and imaging techniques. Scientific Reports, 2019, 9, 1061. doi: 10.1038/s41598-018-37914-8.

Papazian, S., Parrot, D., Buryskova, B., Weinberger, F., Tasdemir, D. Surface chemical defence of the eelgrass Zostera marina against microbial foulers. Scientific Reports 2019, 9, 3323. doi: 10.1038/s41598-019-39212-3.

Heavisides, E., Rouger, C., Reichel, A., Ulrich, C., Wenzel-Storjohann, A., Sebens, S., Tasdemir, D. Seasonal variations in the metabolome and bioactivity profile of Fucus vesiculosus extracted by an optimised pressurised liquid extraction protocol. Marine Drugs, 2018, 16, 503. doi: 10.3390/md16120503.

Chianese G., Esposito, F.P., Parrot D., Ingham, C., de Pascale, D., Tasdemir, D. Linear aminolipids with moderate antimicrobial activity from the Antarctic Gram-negative bacterium Aequorivita sp., Marine Drugs, 2018, 16, 187, doi: 10.3390/md16060187.

Utermann C., Parrot D., Breusing C., Stuckas H., Staufenberger T., Blümel M., Labes A., Tasdemir D. Combined genotyping, microbial diversity and metabolite profiling studies on farmed Mytilus spp. from Kiel Fjord. Scientific Reports 2018, 8:7983, doi: 10.1038/s41598-018-26177-y.

Parrot, D., Papazian, S., Foil, D., Tasdemir D. Imaging the unimaginable: Desorption Electrospray Ionization - Imaging Mass Spectrometry (DESI-IMS) in natural product research. Planta Medica, 2018, doi: 10.1055/s-0044-100188.

Li F., Janussen D., Peifer C., Pérez-Victoria I., Tasdemir, D. Targeted isolation of tsitsikammamines from the Antarctic deep-sea sponge Latrunculia biformis by molecular networking and anticancer activity. Marine Drugs, 2018, 16(8), doi: 10.3390/md16080268.

Smyrniotopoulos, V., Merten, C., Kaiser, M., Tasdemir, D. Bifurcatriol, an Antiprotozoal Acyclic Diterpene from the Brown Alga Bifurcaria bifurcata. Marine Drugs, 2017, 15, 245, doi:10.3390/md15080245.

Silber, J., Kramer, A., Labes, A., Tasdemir, D. From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics. Marine Drugs, 2016, 14(7), 137. doi:10.3390/md14070137.

Merten, C., Smyrniotopoulos, V., Tasdemir, D. Assignment of absolute configurations of highly flexible linear diterpenes from the brown alga Bifurcaria bifurcata by VCD spectroscopy. Chemical Communications, 2015, 51, 16217-16220.

Fernández, A., Grienke, U., Soler-Vila, A., Guihéneuf, F., Stengel, D., Tasdemir, D. Seasonal and geographical variations in the biochemical composition of the blue mussel (Mytilus edulis L.) from Ireland. Food Chemistry, 2015, 177, 43-52.

Grienke, U., Silke, J., Tasdemir, D. Bioactive compounds from marine mussels and their effects on human health. Food Chemistry, 2014, 142, 48-60.

Chianese, G., Fattorusso, E., Scala, F., Teta, R., Calcinai, B., Bavestrello, G., Dien, H.A., Kaiser, M., Tasdemir, D., Taglialatela-Scafati, O. Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin. Organic & Biomolecular Chemistry, 2012, 10, 7197-7207.

Fitzgerald, C., Gallagher, E., Tasdemir, D., Hayes, M. Heart health peptides from macroalgae and their potential use in functional foods. Journal of Agricultural and Food Chemistry, 2011, 59, 6829-6836.

Scala, F., Fattorusso, E., Menna, M., Taglialatela-Scafati, O., Tierney, M., Kaiser, M., Tasdemir, D.  Bromopyrrole alkaloids as lead compounds against protozoan parasites, Marine Drugs, 2010, 8, 2162-2174.

Giddens, A.C., Neilsen, L., Boshoff, H.I., Tasdemir, D., Perozzo, R., Kaiser, M., Wang, F., Sacchettini, J.C., Copp, B.R. Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities. Tetrahedron, 2008, 64, 1242-1249.

Sertan, A.A., Predicala, R.Z., Bernardo, E.B., Neilan, B.A., Elardo, S.P., Mangalindan, G.C., Tasdemir, D., Ireland, C.M., Barraquio, W.L., Concepcion, G.P. Pseudovibrio denitrificans strain Z143-1, a heptyl prodigiosin-producing bacterium isolated from a Philippine tunicate. FEMS Microbiology Letters, 2007, 277, 188-196.

Tasdemir, D., Topaloglu, B., Perozzo, R., Brun, R., O’Neill, R., Carballeira, N.M., Zhang, X., Tonge, P.J., Linden, A., Rüedi, P. Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. Bioorganic & Medicinal Chemistry, 2007, 15, 6834-6845.

Davis, R.A., Mangalindan, G.C., Bojo, Z.P., Antemano, R.R., Rodriguez, N.O., Concepción, G.P., Samson, S.C., de Guzman, D., Cruz, L.J., Tasdemir, D., Harper, M.K., Feng, X., Carter, G.T., Ireland C.M. Microcionamides A and B, Bioactive Peptides from the Philippine Sponge Clathria (Thalysias) abietina. Journal of Organic Chemistry, 2004, 69, 4170-4176.

Marshall, K.M., Matsumoto, S.S., Holden, J.A., Concepcion, G.P., Tasdemir, D., Ireland, C.M., Barrows, L.R. The Anti-neoplastic and Novel Topoisomerase II Mediated Cytotoxicity of Neoamphimedine, a Marine Pyridoacridine. Biochemical Pharmacology, 2003, 66, 447-458.

Tasdemir, D., Mallon, R., Greenstein, M., Feldberg, L.R., Kim, S.C., Collins, K., Wojciechowicz, D., Mangalindan, G.C., Concepción, G.P., Harper, M.K., Ireland, C.M. Aldisine Alkaloids from the Philippine Sponge Stylissa massa are Potent Inhibitors of Mitogen-Activated Protein Kinase Kinase-1 (MEK-1). Journal of Medicinal Chemistry, 2002, 45, 529-532.

Tasdemir, D., Marshall, K.M., Mangalindan, G.C., Concepción, G.P., Barrows, L.R., Harper, M.K., Ireland, C.M. Deoxyamphimedine, a new pyridoacridine alkaloid from two tropical Xestospongia sponges. Journal of Organic Chemistry, 2001, 66, 3246-3248.