GEOMAR  Heuser, Alexander

Alexander Heuser (PhD)

RD 2: Marine Biogeochemistry
RU Marine Geosysteme 

Office: 8E/107, phone (office): +49 431 600 2114

E-mail: aheuser(at)geomar.de

Contact

Address: GEOMAR Helmholtz Centre for Ocean Research Kiel, Wischhofstraße 1-3, 24148 Kiel, Germany

Research Focus

U/Th dating of marine carbonates, Ca isotope geochemistry, biomedical application of the Ca isotope system

Projects

2023-2026 Osteo-Frak-Risk "Fracture risk determination of osteoporotic fractures using the innovative calcium biomarker”

Vita

since 2016: Research Associate, GEOMAR Helmholtz Center for Ocean Research Kiel

2007-2015: Research Associate, Steinmann Institute for Geology, Mineralogy and Paleontology, University of Bonn

2003-2007: Research Associate, Leibniz Institute of Marine Sciences (IFM-Geomar)

1999-2003: PhD student, Research Training Group “Dynamics of Global Cycles in the Earth System”, Kiel

1993-1998: Study of Mineralogy, Degree: Dipl. Min., University of Göttingen

Publications (OceanRep)

Jump to: Articles in a Scientific Journal - peer-reviewed | Articles in a Scientific Journal - without review | Presentations | Conference posters
Number of items: 38.

Articles in a Scientific Journal - peer-reviewed

[thumbnail of coombs-et-al-2025-bone-calcium-balance-following-an-antarctic-expedition.pdf]

Coombs, C. V., Capella, S., Taylor, N., Gifford, R. M., Eisenhauer, A. , Kolevica, A., Heuser, A. , Koivula, F., Greeves, J. P. and O’Leary, T. J. (In Press / Accepted) Bone Calcium Balance Following an Antarctic Expedition. Open Access Journal of Applied Physiology . DOI 10.1152/japplphysiol.00849.2025.

[thumbnail of 1-s2.0-S8756328225001346-main.pdf] [thumbnail of 1-s2.0-S8756328225001346-mmc1.docx]

Eisenhauer, A. , Sönnichsen, S., Hastuti, A., Shroff, R., Heuser, A. , Kolevica, A., Lubnow, A., Brandt, B. and Müller, M. (2025) Monitoring denosumab therapy using the calcium isotope marker (CIM) technology. Open Access Bone, 198 . Art.Nr. 117522. DOI 10.1016/j.bone.2025.117522.

[thumbnail of Coombs.pdf]

Coombs, C. V., Greeves, J. P., Young, C. D., Irving, A. S., Eisenhauer, A. , Kolevica, A., Heuser, A. , Tang, J. C. Y., Fraser, W. D. and O’Leary, T. J. (2025) The effect of calcium supplementation on bone calcium balance and calcium and bone metabolism during load carriage in women: a randomised controlled crossover trial. Journal of Bone and Mineral Research, 40 (6). pp. 753-765. DOI 10.1093/jbmr/zjaf004.


Eisenhauer, A. , Heuser, A. , Kolevica, A., Shroff, R., Brandt, B., Lubnow, A., Hastuti, A. and Müller, M. (2025) Ein korrelationsbasierter Ansatz zur Vorhersage von DXA T-score Werten mittels des Calcium-Isotopen-Markers (CIM). Osteologie, 34 (2). pp. 156-157. DOI 10.1055/s-0045-1804995.

[thumbnail of 1-s2.0-S8756328224001996-main.pdf] [thumbnail of 1-s2.0-S8756328224001996-mmc1(1).docx]

Eisenhauer, A. , Hastuti, A., Heuser, A. , Kolevica, A., Brandt, B., Shroff, R., Oehme, J. and Müller, M. (2024) Calcium isotope composition in serum and urine for the assessment of bone mineral balance (BMB) – The Osteolabs post-market follow-up study. Open Access Bone, 188 . Art.Nr. 117210. DOI 10.1016/j.bone.2024.117210.

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Rott, J., Töpfer, E. T., Bartosova, M., Damgov, I., Kolevica, A., Heuser, A. , Shroff, R., Zarogiannis, S. G., Eisenhauer, A. and Schmitt, C. P. (2023) Calcimimetic AMG-416 induced short-term changes in calcium concentrations and calcium isotope ratios in rats. Biochemical and Biophysical Research Communications, 677 . pp. 88-92. DOI 10.1016/j.bbrc.2023.07.060.


Harrison, A. L., Heuser, A. , Liebetrau, V., Eisenhauer, A. , Schott, J. and Mavromatis, V. (2023) Equilibrium Ca isotope fractionation and the rates of isotope exchange in the calcite-fluid and aragonite-fluid systems at 25 °C. Earth and Planetary Science Letters, 603 . Art.Nr. 117985. DOI 10.1016/j.epsl.2022.117985.

[thumbnail of 1-s2.0-S008525382200374X-main.pdf] [thumbnail of 1-s2.0-S008525382200374X-mmc1.docx]

Shroff, R., Lalayiannis, A. D., Fewtrell, M., Schmitt, C. P., Bayazit, A., Askiti, V., Jankauskiene, A., Bacchetta, J., Silva, S., Goodman, N., McAlister, L., Biassoni, L., Crabtree, N., Rahn, A., Fischer, D. C., Heuser, A. , Kolevica, A. and Eisenhauer, A. (2022) Naturally occurring stable calcium isotope ratios are a novel biomarker of bone calcium balance in chronic kidney disease. Open Access Kidney International, 102 (3). pp. 613-623. DOI 10.1016/j.kint.2022.04.024.

[thumbnail of ijms-23-07796-v2.pdf] [thumbnail of ijms-23-07796-s001.zip]

Rott, J., Toepfer, E. T., Bartosova, M., Kolevica, A., Heuser, A. , Rabe, M., Behets, G., D’Haese, P. C., Eichwald, V., Jugold, M., Damgov, I., Zarogiannis, S. G., Shroff, R., Eisenhauer, A. and Schmitt, C. P. (2022) Nutritional Calcium Supply Dependent Calcium Balance, Bone Calcification and Calcium Isotope Ratios in Rats. Open Access International Journal of Molecular Sciences, 23 (14). Art.Nr. 7796. DOI 10.3390/ijms23147796.

[thumbnail of Toepfer et al.pdf]

Toepfer, E. T., Rott, J., Bartosova, M., Kolevica, A., Machuca-Gayet, I., Heuser, A. , Rabe, M., Shroff, R., Bacchetta, J., Zarogiannis, S. G., Eisenhauer, A. and Schmitt, C. P. (2021) Calcium isotope fractionation by osteoblasts and osteoclasts, across endothelial and epithelial cell barriers and with binding to proteins. Open Access American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 321 (1). R29-R40. DOI 10.1152/ajpregu.00334.2020.

[thumbnail of jbmr.4158.pdf] [thumbnail of jbmr4158-sup-0001-supinfo.docx]

Shroff, R., Fewtrell, M., Heuser, A. , Kolevica, A., Lalayiannis, A., McAlister, L., Silva, S., Goodman, N., Schmitt, C. P., Biassoni, L., Rahn, A., Fischer, D. and Eisenhauer, A. (2021) Naturally occurring stable calcium isotope ratios in body compartments provide a novel biomarker of bone mineral balance in children and young adults. Open Access Journal of Bone and Mineral Research, 36 (1). pp. 133-142. DOI 10.1002/jbmr.4158.

[thumbnail of [1479683X - European Journal of Endocrinology] Early effects of androgen deprivation on bone and mineral homeostasis in adult men_ a prospective cohort study.pdf]

Khalil, R., Antonio, L., Laurent, M. R., David, K., Kim, N. R., Evenepoel, P., Eisenhauer, A. , Heuser, A. , Cavalier, E., Khosla, S., Claessens, F., Vanderschueren, D. and Decallonne, B. (2020) Early effects of androgen deprivation on bone and mineral homeostasis in adult men: a prospective cohort study. Open Access European Journal of Endocrinology, 183 (2). pp. 181-189. DOI 10.1530/EJE-20-0348.

Liu, H., Xiao, Y., Sun, H., Tong, F., Heuser, A. , Churikova, T. and Wörner, G. (2020) Trace elements and Li isotope compositions across the Kamchatka arc: Constraints on slab‐derived fluid sources. Open Access Journal of Geophysical Research: Solid Earth, 125 (5). Art.Nr. e2019JB019237. DOI 10.1029/2019JB019237.

[thumbnail of Schmidt_et_al-2019-Geochemistry,_Geophysics,_Geosystems.pdf]

Schmidt, C. , Hensen, C. , Wallmann, K. , Liebetrau, V., Tatzel, M., Schurr, S. L., Kutterolf, S. , Haffert, L., Geilert, S. , Hübscher, C. , Lebas, E. , Heuser, A. , Schmidt, M. , Strauss, H. , Vogl, J. and Hansteen, T. (2019) Origin of high Mg and SO 4 fluids in sediments of the Terceira Rift, Azores – indications for caminite dissolution in a waning hydrothermal system. Open Access Geochemistry, Geophysics, Geosystems, 20 . DOI 10.1029/2019GC008525.

[thumbnail of 1-s2.0-S2352187219300063-main.pdf]

Eisenhauer, A. , Müller, M., Heuser, A. , Kolevica, A., Glüer, C. C., Both, M., Laue, C., Hehn, U. v., Kloth, S., Shroff, R. and Schrezenmeir, J. (2019) Calcium isotope ratios in blood and urine: A new biomarker for the diagnosis of osteoporosis. Open Access Bone Reports, 10 . Art.Nr. 100200. DOI 10.1016/j.bonr.2019.100200.

[thumbnail of fphys-10-00012.pdf]

Heuser, A. , Frings-Meuthen, P., Rittweger, J. and Galer, S. J. G. (2019) Calcium Isotopes in Human Urine as a Diagnostic Tool for Bone Loss: Additional Evidence for Time Delays in Bone Response to Experimental Bed Rest. Open Access Frontiers in Physiology, 10 (Article 12). DOI 10.3389/fphys.2019.00012.

[thumbnail of Pohl_et_al-2018-Tectonics(1).pdf]

Pohl, F., Froitzheim, N., Obermüller, G., Tomaschek, F., Schröder, O., Nagel, T. J., Sciunnach, D. and Heuser, A. (2018) Kinematics and Age of Syn-Intrusive Detachment Faulting in the Southern Alps: Evidence for Early Permian Crustal Extension and Implications for the Pangea A Versus B Controversy. Open Access Tectonics, 37 (10). pp. 3668-3689. DOI 10.1029/2018TC004974.

[thumbnail of Kirchenbaur et al (2018).pdf]

Kirchenbaur, M., Heuser, A. , Bragagni, A. and Wombacher, F. (2018) Determination of In and Sn Mass Fractions in Sixteen Geological Reference Materials by Isotope Dilution MC-ICP-MS. Geostandards and Geoanalytical Research, 42 (3). pp. 361-377. DOI 10.1111/ggr.12211.

[thumbnail of Bragagni.pdf]

Bragagni, A., van Acken, D., Fonseca, R. O. C., Speelmanns, I. M., Wainwright, A. N., Heuser, A. , Nowell, G. M. and Luguet, A. (2018) Re-Os and HSE in individual base metal sulfide grains: Evaluating micro-analytical procedures using a sulfide reference material. Chemical Geology, 493 . pp. 426-440. DOI 10.1016/j.chemgeo.2018.06.020.

[thumbnail of Gäb.pdf]

Gäb, F., Ballhaus, C., Siemens, J., Heuser, A. , Lissner, M., Geisler, T. and Garbe-Schönberg, D. (2017) Siderite cannot be used as CO2 sensor for Archaean atmospheres. Geochimica et Cosmochimica Acta, 214 . pp. 209-225. DOI 10.1016/j.gca.2017.07.027.

[thumbnail of Ballhaus.pdf]

Ballhaus, C., Fonseca, R. O. C., Münker, C., Rohrbach, A., Nagel, T., Speelmanns, I. M., Helmy, H. M., Zirner, A., Vogel, A. K. and Heuser, A. (2017) The great sulfur depletion of Earth’s mantle is not a signature of mantle–core equilibration. Contributions to Mineralogy and Petrology, 172 (8, Article 68). DOI 10.1007/s00410-017-1388-3.

[thumbnail of Fonseca.pdf] [thumbnail of Fonseca_mmc1(12).pdf]

Fonseca, R. O. C., Kirchenbaur, M., Ballhaus, C., Münker, C., Zirner, A., Gerdes, A., Heuser, A. , Botcharnikov, R. and Lenting, C. (2017) Fingerprinting fluid sources in Troodos ophiolite complex orbicular glasses using high spatial resolution isotope and trace element geochemistry. Geochimica et Cosmochimica Acta, 200 . pp. 145-166. DOI 10.1016/j.gca.2016.12.012.

[thumbnail of Heuser et al (2016).pdf]

Heuser, A. , Eisenhauer, A. , Scholz-Ahrens, K. E. and Schrezenmeir, J. (2016) Biological fractionation of stable Ca isotopes in Göttingen minipigs as a physiological model for Ca homeostasis in humanS. Isotopes in Environmental and Health Studies, 52 (6). pp. 633-648. DOI 10.1080/10256016.2016.1151017.

Leitzke, F. P., Fonseca, R. O. C., Michely, L. T., Sprung, P., Münker, C., Heuser, A. and Blanchard, H. (2016) The effect of titanium on the partitioning behavior of high-field strength elements between silicates, oxides and lunar basaltic melts with applications to the origin of mare basalts. Chemical Geology, 440 . pp. 219-238. DOI 10.1016/j.chemgeo.2016.07.011.

[thumbnail of j.1751-908X.2008.00877.x.pdf]

Heuser, A. and Eisenhauer, A. (2008) The Calcium Isotope Composition (δ44/40Ca) of NIST SRM 915b and NIST SRM 1486. Geostandards and Geoanalytical Research, 32 (2). pp. 27-32. DOI 10.1111/j.1751-908X.2008.00877.x.

[thumbnail of 2003_Gussone_etal_GCA.pdf]

Gussone, N., Eisenhauer, A. , Heuser, A. , Dietzel, M., Bock, B., Böhm, F., Spero, H., Lea, D. W., Bijma, J., Zeebe, R. and Nägler, T. F. (2003) Model for kinetic effects on calcium isotope fractionation (δ<sup>44<\sup>Ca) in inorganic aragonite and cultured planktonic foraminifera. Geochimica et Cosmochimica Acta, 67 (7). pp. 1375-1382. DOI 10.1016/S0016-7037(02)01296-6.

[thumbnail of Hippler.pdf]

Hippler, D., Schmitt, A. D., Gussone, N., Heuser, A. , Stille, P., Eisenhauer, A. and Nägler, T. F. (2003) Calcium isotopic composition of various standards and seawater. Geostandards Newsletter, 27 (1). pp. 13-19. DOI 10.1111/j.1751-908X.2003.tb00709.x.

[thumbnail of 2002_Heuser_Eisenhauer_etal_IJMSp.pdf]

Heuser, A. , Eisenhauer, A. , Gussone, N., Bock, B., Hansen, B. T. and Nägeler, T. F. (2002) Measurement of calcium isotopes (δ44Ca) using a multicollector TIMS technique. International Journal of Mass Spectrometry, 220 (3). pp. 385-397. DOI 10.1016/S1387-3806(02)00838-2.

Articles in a Scientific Journal - without review

[thumbnail of egusphere-2025-4126-1.pdf] [thumbnail of egusphere-2025-4126-supplement.pdf]

Yu, Y. , Hathorne, E. , Chen, X., Wei, G., Böhm, F., Heuser, A. , Eisenhauer, A. , Siebert, C. and Frank, M. (Submitted) Deconvolving the biogeochemical controls on coral Sr/Ca and Ba/Ca proxies: New perspectives from paired stable Ca, Sr and Ba isotope compositions. Open Access EGUsphere . DOI 10.5194/egusphere-2025-4126.


Eisenhauer, A. , Sönnichsen, S., Heuser, A. , Kolevica, A., Lutz, M., Lubnow, A. and Müller, M. (2025) Denosumab-Therapie Monitoring mit Hilfe der Calcium-Isotopenmarker (CIM)-Technologie. Osteologie, 34 (02). Art.Nr.: 146. DOI 10.1055/s-0045-1804972.


Shroff, R., Eisenhauer, A. , Heuser, A. , Kolevica, A., Mueller, M., D'Haese, P. and Evenepoel, P. (2023) Calcium Isotope Ratios in Serum: A Novel Biomarker of Bone and Vessel Calcium Balance in Patients on Dialysis: TH-OR38. Journal of the American Society of Nephrology, 34 (11S). pp. 11-12. DOI 10.1681/ASN.20233411S111c.

[thumbnail of Abstract]

Shroff, R., Eisenhauer, A. , Heuser, A. , Kolevica, A., D'haese, P., Shanahan, C. and Evenepoel, P. (2023) Calcium isotope ratios in serum are the strongest predictor of bone calcium balance in patients on dialysis. Open Access Nephrology Dialysis Transplantation, 38 (Supplement_1). Art.Nr. gfad063c_3539. DOI 10.1093/ndt/gfad063c_3539.

Presentations


Eisenhauer, A. , Heuser, A. , Kolevica, A. and Müller, M. (2023) Early detection of bone demineralization associated with osteoporosis through the non-invasive measurement of naturally occuring calcium (CA) isotope ratios (CA-44/CA-42) in serum and urine. [Talk] In: World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2023). , 04.5.-7.5.2023, Barcelona, Spain . Abstract in: Aging Clinical and Experimental Research Volume 35, Page S383, Supplement 1, Meeting Abstract P735. .

[thumbnail of Abstract]

Freitas, M. L., Geilert, S. , Heuser, A. , Wallmann, K. and Magalhaes, V. H. (2023) Serpentinite Mud Volcanoes as Natural Laboratory for Mineral Carbonation Reactions. Open Access [Talk] In: Goldschmidt Conference 2023. , 9.-14.07.2023, Lyon, France .

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Eisenhauer, A. , Böhm, F., Fietzke, J. , Liebetrau, V., Amini, M., Kisakurek, B., Heuser, A. , Tang, J. and Dietzel, M. (2008) The application of natural divalent cation isotope (Ca, Sr, Mg) fractionation (DCIF) in earth system research. Open Access [Talk] In: Goldschmidt Conference 2008. , 13.-18.07.2008, Vancouver, Canada .

Conference posters

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Harrison, A., Mavromatis, V., Schott, J., Heuser, A. , Liebetrau, V. and Eisenhauer, A. (2023) Isotope exchange mechanisms between CaCO 3 and fluid at chemical equilibrium. Open Access [Poster] In: Goldschmidt Conference 2023. , 9.-14.07.2023, Lyon, France .


Schmidt, C. , Hensen, C. , Wallmann, K. , Liebetrau, V., Tatzel, M., Schurr, S. L., Kutterolf, S. , Haffert, L., Hübscher, C., Lebas, E. , Heuser, A. , Schmidt, M. , Struss, H., Vogl, H. and Hansteen, T. H. (2019) Caminite: An underestimated metastable Mg reservoir in hydrothermal recharge zones?. [Poster] In: AGU Fall Meeting 2019. , 09.-13.12.2019, San Francisco, USA .


Obermüller, G., Pohl, F., Tomaschek, F., Heuser, A. , Froitzheim, N., Sciunnach, D. and Schröder, O. (2016) Permian detachment faulting and syntectonic magmatism constrained by U-Pb LA-ICP-MS on zircon in the Orobic Anticline, Italy. [Poster] In: GeoTirol 2016. , 25.-28.10.2016, Innsbruck, Austria .

This list was generated on Thu Dec 4 21:12:49 2025 CET.